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Olanzapine uses

Olanzapine is an atypical antipsychotic, approved by the FDA in 1996. Olanzapine is manufactured and marketed by the pharmaceutical company Eli Lilly and Company. Elderly patients with dementia-related psychosis treated with antipsychotics are at an increased risk of death compared with placebo. Most deaths appeared to be either cardiovascular eg, heart failure, sudden death or infectious eg, pneumonia in nature. Use with caution in patients with Lewy body dementia or Parkinson disease dementia due to greater risk of adverse effects, increased sensitivity to extrapyramidal effects, and association with irreversible cognitive decompensation or death. generic anafranil liquid

Olanzapine forms and strengths

September 27, 2016. Tips for tapering off Zyprexa olanzapine - Tapering. The American College of Obstetricians and Gynecologists ACOG has released guidelines on psychiatric medication used by women during pregnancy and lactation. Adverse events were observed in animal reproduction studies. Olanzapine crosses the placenta and can be detected in cord blood at birth Newport 2007. Information related to olanzapine use in pregnancy is limited Goldstein 2000. N-desmethyl olanzapine, present at steady state at 31% of the concentration of olanzapine. Both metabolites lack pharmacological activity at the concentrations observed.

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Zyprexa Zydis orally disintegrating tablets may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills. Cimetropium: Anticholinergic Agents may enhance the anticholinergic effect of Cimetropium. November 18, 2016. ACOG Guidelines on Psychiatric Medication Use During.

Reviews for olanzapine

If your condition persists or worsens, contact your doctor or pharmacist. Delirium off-label use: Oral: 5 mg once daily for up to 5 days NICE 2010. Please check other sub-forums first to see if your problem should be posted. Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil from the tablet blister. Do not push a tablet through the foil or you may damage the tablet. Special thanks to Dr. Ron Browning, Dept. of Physiology, School of Medicine, Southern Illinois University Carbondale for his contribution to, and review of, this.



List of olanzapine side effects

Olanzapine injection can cause serious symptoms if the medicine gets into your bloodstream too fast. Multiple doses of olanzapine did not influence the kinetics of biperiden. There are no adequate and well-controlled trials with olanzapine in pregnant females. Seven pregnancies were observed during clinical trials with olanzapine, including 2 resulting in normal births, 1 resulting in neonatal death due to a cardiovascular defect, 3 therapeutic abortions, and 1 spontaneous abortion. Cyproterone: May decrease the serum concentration of CYP1A2 Substrates. Teriflunomide: May decrease the serum concentration of CYP1A2 Substrates. Olanzapine for injection results in rapid absorption with peak plasma concentrations occurring within 15 to 45 minutes. If you have any questions about Zyprexa Zydis orally disintegrating tablets, please talk with your doctor, pharmacist, or other health care provider. LDL cholesterol, total cholesterol, triglycerides, prolactin, and liver transaminase levels when compared with adults. Adolescent patients should be maintained on the lowest dose necessary. This may not be a complete list of all interactions that may occur. Ask your health care provider if olanzapine tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. Neonatal withdrawal syndrome following in utero exposure to paroxetine, clonazepam and olanzapine. COSTART terms were counted in this category: akinesia, cogwheel rigidity, extrapyramidal syndrome, hypertonia, hypokinesia, masked facies, tremor. Cerebrovascular effects: An increased incidence of cerebrovascular effects eg, transient ischemic attack, stroke including fatalities, has been reported in placebo-controlled trials of olanzapine for the unapproved use in elderly patients with dementia-related psychosis. CLASS facts using a simple interactive process flashcard, matching, or multiple choice. Finally a format that helps you.



Refer to adult dosing

Do not suddenly stop taking Zyprexa Zydis orally disintegrating tablets without checking with your doctor. Protect olanzapine for injection from light, do not freeze. Some olanzapine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Paul A. Law, MD, MPH, and Kiely Law, MD, MPH, researchers at the Kennedy Krieger Institute and parents of Isaac, a child with autism last year launched the Interactive Autism Network IAN. In patients who do require chronic treatment, the smallest dose and the shortest duration of treatment producing a satisfactory clinical response should be sought. The need for continued treatment should be reassessed periodically. Talk to your doctor about using this medication safely. Tetrahydrocannabinol: May enhance the CNS depressant effect of CNS Depressants. Check the labels on all your medicines such as or -and-cold products because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely. Zyprexa Zydis orally disintegrating tablets comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Zyprexa Zydis orally disintegrating tablets refilled. Other drugs may interact with olanzapine injection, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking olanzapine, do not stop taking it without your doctor's advice. Anti-Parkinson Agents Dopamine Agonist. Management: Consider using an alternative antipsychotic agent when possible in patients with Parkinson disease. If an atypical antipsychotic is necessary, consider using clozapine or quetiapine, which may convey the lowest interaction risk. chantix



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Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. Patients should be advised to change positions carefully to help prevent orthostatic hypotension, and to lie down if they feel dizzy or faint, until they feel better. Patients should be advised to call their doctor if they experience any of the following signs and symptoms associated with orthostatic hypotension: dizziness, fast or slow heart beat, or fainting. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. This medication may rarely cause a very serious condition called NMS. This medication is given by injection into the buttock muscle by a professional as directed by your doctor, usually every 2 to 4 weeks. Olanzapine can pass into breast milk and may harm a nursing baby. You may need to stop breast-feeding for a short time after receiving an olanzapine injection. Follow your doctor's instructions. Olanzapine has not been systematically studied in humans for its potential for abuse, tolerance, or physical dependence. September 26, 2016. Zyprexa Olanzapine - Reviews, Ratings. Established in 1932, Deli Brands of America has a tradition of quality and value that is unsurpassed. Maximum plasma concentrations after IM administration are 5 times higher than maximum plasma concentrations produced by an oral dose. Which is better: Olanzapine or Xanax? The possibility of multiple drug involvement should be considered. In case of acute overdosage, establish and maintain an airway and ensure adequate oxygenation and ventilation, which may include intubation. Gastric lavage after intubation, if patient is unconscious and administration of activated charcoal together with a laxative should be considered. salbutamol stock price morningstar salbutamol



This page provides information on the

COSTART terms were counted in this category: dystonia, generalized spasm, neck rigidity, oculogyric crisis, opisthotonos, torticollis. October 26, 2016. OLANZapine Professional Patient Advice - Drugs. Peginterferon Alfa-2b: May increase the serum concentration of CYP1A2 Substrates. Alberta Sulphur Research Ltd. was incorporated as a not-for-profit research organization in 1964. Swallow several times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet. Avoid becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking olanzapine. Table 3 shows short-term and long-term changes in fasting blood glucose from adolescent olanzapine monotherapy studies. Drug Reaction with Eosinophilia and Systemic Symptoms DRESS hepatitis, jaundice, neutropenia, pancreatitis, priapism, rash, rhabdomyolysis, and venous thromboembolic events including pulmonary embolism and deep venous thrombosis. February 8, 2016. olanzapine, Zyprexa, Zydis, Relprevv: Drug Facts and Side. Overall, there was no difference in the incidence of discontinuation due to adverse reactions 5% for oral olanzapine vs 6% for placebo. However, discontinuations due to increases in ALT were considered to be drug related 2% for oral olanzapine vs 0% for placebo. ALT aspartate aminotransferase AST and hepatic enzyme were combined under liver enzymes. What should I discuss with my healthcare provider before receiving olanzapine injection? Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur. What should I avoid after receiving olanzapine injection? May 6, 2016. ZYPREXA Olanzapine dosage, indication, interactions. Mianserin: May enhance the anticholinergic effect of Anticholinergic Agents. generic for bimatoprost



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March 14, 2016. Olanzapine: Indications, Side Effects, Warnings - Drugs. Monoamine oxidase inhibitors MAOIs are chemicals that inhibit the activity of the monoamine oxidase enzyme family. They have a long history of use as medications. Antipsychotic drugs have been shown to chronically elevate prolactin levels in rodents. Serum prolactin levels were not measured during the olanzapine carcinogenicity studies; however, measurements during subchronic toxicity studies showed that olanzapine elevated serum prolactin levels up to 4-fold in rats at the same doses used in the carcinogenicity study. An increase in mammary gland neoplasms has been found in rodents after chronic administration of other antipsychotic drugs and is considered to be prolactin mediated. Olanzapine: uses, dose, side effects and warnings. We explain everything you should know if you've been prescribed olanzapine for schizophrenia or bipolar. Orally-disintegrating: Remove from foil blister by peeling back do not push tablet through the foil; place tablet in mouth immediately upon removal; tablet dissolves rapidly in saliva and may be swallowed with or without liquid. Of the 2500 patients in premarketing clinical studies with oral olanzapine, 11% 263 were 65 years of age or over. In patients with schizophrenia, there was no indication of any different tolerability of olanzapine in the elderly compared to younger patients. Studies in elderly patients with dementia-related psychosis have suggested that there may be a different tolerability profile in this population compared to younger patients with schizophrenia. Elderly patients with dementia-related psychosis treated with olanzapine are at an increased risk of death compared to placebo. Treatment. Bipolar disorder is a recurrent disease that can be unpredictable. The major goals of treatment are to: Treat and reduce the. CNS depressants. No such dose change is recommended for women. Avoid use with other CNS depressants at bedtime; avoid use with alcohol. June 20, 2016. What are some drug interactions for anti-anxiety drugs. COSTART terms were counted in this category: buccoglossal syndrome, choreoathetosis, dyskinesia, tardive dyskinesia. Although the causes of death were varied, most of the deaths appeared to be either cardiovascular eg, heart failure, sudden death or infectious eg, pneumonia in nature. Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristics of the patient is not clear. Olanzapine is not approved for treatment of patients with dementia-related psychosis.



What are the possible side effects of olanzapine

Do not drink alcohol while you are taking Zyprexa Zydis orally disintegrating tablets. Buprenorphine: CNS Depressants may enhance the CNS depressant effect of Buprenorphine. Reports have been received of fatality in association with overdose of olanzapine alone. If the medication releases too quickly, your drug levels may be too high. Hepatic impairment: Use with caution in patients with hepatic disease or impairment; may increase transaminases primarily ALT. Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed. Hyperglycemia: Atypical antipsychotics have been associated with development of hyperglycemia; in some cases, may be extreme and associated with ketoacidosis, hyperosmolar coma, or death. Olanzapine may have a greater association with hyperglycemia than other atypical antipsychotics. Use with caution in patients with diabetes or other disorders of glucose regulation; monitor for worsening of glucose control. Patients with risk factors for diabetes eg, obesity or family history should have a baseline fasting blood sugar FBS and periodic assessment of glucose regulation. If you have any questions, consult your doctor or pharmacist. Obeticholic Acid: May increase the serum concentration of CYP1A2 Substrates. Budman 2001; Onofrj 2000; Stamenkovic 2000. Attach a new safety needle to the syringe. Slowly withdraw the desired amount into the syringe. Some excess product will remain in the vial. Engage the needle safety device and remove needle from syringe. NMS is a possibly fatal syndrome that can be caused by Zyprexa Zydis orally disintegrating tablets. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms. Discontinue olanzapine if DRESS is suspected. Zolpidem: CNS Depressants may enhance the CNS depressant effect of Zolpidem. This drug is not indicated as monotherapy for the treatment of depressive episodes associated with bipolar I disorder. ER. Olanzapine ER must be administered in a registered health care facility with ready access to emergency response services. After each injection, patients must be observed at the health care facility by a health care provider for at least 3 hours. Because of this risk, olanzapine ER is available only through a restricted distribution program called Zyprexa Relprevv Patient Care Program, and requires health care provider, health care facility, patient, and pharmacy enrollment. generic hydrochlorothiazide online fda



Use of olanzapine

Concomitant administration of intramuscular olanzapine and parenteral benzodiazepine is not recommended due to the potential for excessive sedation and cardiorespiratory depression. Nitroglycerin: Anticholinergic Agents may decrease the absorption of Nitroglycerin. Specifically, anticholinergic agents may decrease the dissolution of sublingual nitroglycerin tablets, possibly impairing or slowing nitroglycerin absorption. In pooled studies of adults as well as pooled studies of adolescents, there were no significant differences between olanzapine and placebo in the proportions of patients experiencing potentially important changes in ECG parameters, including QT, QTc Fridericia corrected and PR intervals. Talk with your doctor before you use medicines that may cause drowsiness eg, sleep aids, muscle relaxers while you are taking olanzapine tablets; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness. There is no specific antidote to olanzapine. Therefore, appropriate supportive measures should be initiated. Treatment-resistant depression in combination with fluoxetine: Oral: Initial: 5 mg in the evening; adjust as tolerated to range of 5 to 20 mg daily. See "Note. Consult your doctor before -feeding. Professional guide for OLANZapine. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more. In some cases, this condition may be permanent. ipow.info periactin



What is olanzapine

The percentages of patients who gained at least 7%, 15%, or 25% of their baseline body weight with long-term exposure were 64%, 32%, and 12%, respectively. Zyprexa Zydis orally disintegrating tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people. Infrequent: epistaxis; Rare: lung edema. Olanzapine is not approved for the treatment of patients with dementia-related psychosis. Do not become overheated or dehydrated in hot weather or while you are being active; heatstroke may occur. NMS has been reported in association with administration of antipsychotic drugs, including olanzapine. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac dysrhythmia. Additional signs may include elevated creatinine phosphokinase, myoglobinuria rhabdomyolysis and acute renal failure. Zyprexa olanzapine which is used to treat schizophrenia and manic episodes in bipolar disorder. Physician reviewed olanzapine oral patient information - includes olanzapine description, dosage and directions. WBC followed until recovery. Lofexidine: May enhance the CNS depressant effect of CNS Depressants. For specific information about the contraindications of lithium or valproate, refer to the Contraindications section of the package inserts for these other products. This page provides information on the. Esophageal dysmotility and aspiration have been associated with antipsychotic drug use. Aspiration pneumonia is a common cause of morbidity and mortality in patients with advanced Alzheimer's disease. Olanzapine is not approved for the treatment of patients with Alzheimer's disease. Clonazepam, sold under the brand name Klonopin among others, is a medication used to prevent and treat seizures, panic disorder, and for the movement disorder known. Patients and caregivers should be counseled that a potentially fatal symptom complex sometimes referred to as NMS has been reported in association with administration of antipsychotic drugs, including olanzapine. amiloride



Side effects of olanzapine

Olanzapine is not approved for the treatment of dementia-related psychosis. Somnolence was reported in 8% of patients receiving IM extended-release suspension. An olanzapine injection is usually given only once. If you still have symptoms after 2 hours, your caregivers may use a second or third dose. Table 2 shows short-term and long-term changes in fasting glucose levels from adult olanzapine monotherapy studies. Oral carcinogenicity studies were conducted in mice and rats. Blonanserin: CNS Depressants may enhance the CNS depressant effect of Blonanserin. Post-traumatic stress disorder off-label use: Oral: Initial: 5 to 10 mg daily; adjust dose based on response and tolerability every 1 to 2 weeks, up to 20 mg daily Carey 2012; Stein 2002. For the collection of adverse reactions, the term personality disorder was used to collect data on nonaggressive objectionable behavior. Clearance of olanzapine is approximately 30% lower in women than in men. There were, however, no apparent differences between men and women in effectiveness or adverse effects. Dosage modifications based on gender should not be needed. Zyprexa Zydis orally disintegrating tablets may come in a bottle or a blister pack. If it comes in a blister pack, do not remove the blister from the outer pouch until you are ready to take Zyprexa Zydis orally disintegrating tablets. Do not push the tablet through the foil. Peel back the foil on the blister pack and place the tablet on your tongue. Take the tablet immediately after opening the blister pack. Do not store the removed tablet for future use. Below are Zyprexa Olanzapine reviews, ratings, comments submitted by patients and caregivers. Fluvoxamine: Fluvoxamine, a CYP1A2 inhibitor, decreases the clearance of olanzapine. This results in a mean increase in olanzapine Cmax following fluvoxamine of 54% in female nonsmokers and 77% in male smokers. The mean increase in olanzapine AUC is 52% and 108%, respectively. Lower doses of olanzapine should be considered in patients receiving concomitant treatment with fluvoxamine. Learn All About Depression: General info, Causes, Diagnosis, Treatment, Medication, etc. Free online information, discussions, support, book recommendations, and more.



How should i take olanzapine

Symbyax, created by Eli Lilly and Company is a single capsule containing the atypical antipsychotic olanzapine and the selective. Secretin: Anticholinergic Agents may diminish the therapeutic effect of Secretin. Management: Avoid using drugs with substantial anticholinergic effects in patients receiving secretin whenever possible. If such agents must be used in combination, monitor closely for a diminished response to secretin. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take see section. Page 1 of 2 - Tips for tapering off Zyprexa olanzapine - posted in Tapering: Olanzapine is an atypical antipsychotic with a number of serious drug interactions and. UC Small Farm Program - Home. Ramosetron: Anticholinergic Agents may enhance the constipating effect of Ramosetron. If your symptoms do not improve or if they become worse, check with your doctor. Dosage is based on your medical condition and response to treatment. Polysorbate 80: Some dosage forms may contain polysorbate 80 also known as Tweens. Hypersensitivity reactions, usually a delayed reaction, have been reported following exposure to pharmaceutical products containing polysorbate 80 in certain individuals Isaksson 2002; Lucente 2000; Shelley 1995. Thrombocytopenia, ascites, pulmonary deterioration, and renal and hepatic failure have been reported in premature neonates after receiving parenteral products containing polysorbate 80 Alade 1986; CDC 1984. Extended-release olanzapine injection is a long-acting psychiatric called an atypical antipsychotic. Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? Some patients who take Zyprexa Zydis orally disintegrating tablets may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take Zyprexa Zydis orally disintegrating tablets in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements while taking Zyprexa Zydis orally disintegrating tablets. Freudenmann 2008; Heller 2013. Additional data may be necessary to further define the role of olanzapine in this condition. Therapeutic Research Faculty 2009. No evidence of bone marrow cytotoxicity was found in any of the species examined. Bone marrows were normocellular or hypercellular, indicating that the reductions in circulating blood cells were probably due to peripheral non-marrow factors. Doxylamine: May enhance the CNS depressant effect of CNS Depressants. can i take unisom



Olanzapine warnings

Drinking extra fluids while you are taking Zyprexa Zydis orally disintegrating tablets is recommended. Check with your doctor for instructions. The effect of olanzapine on labor and delivery in humans is unknown. Parturition in rats was not affected by olanzapine. This drug may cause significant weight gain and a rise in your or levels, especially in teenagers. Teva is the largest generic manufacturer in the world. Learn more about our medicines and generic drugs. Make sure that your hands are dry before you touch Zyprexa Zydis orally disintegrating tablets. price for varenicline at walgreens



Does olanzapine interact with other medications

The dosage is based on your medical condition and response to treatment. June 22, 2016. Post-Traumatic Stress Disorder Medications - Post. April 30, 2017. Tips for tapering off Zyprexa olanzapine - Tapering. Increased Mortality in Elderly Patients with Dementia-Related Psychosis - Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Patients with the following COSTART terms were counted in this category: akinesia, cogwheel rigidity, extrapyramidal syndrome, hypertonia, hypokinesia, masked facies, tremor. COSTART terms were counted in this category: akathisia, hyperkinesia. Vemurafenib: May increase the serum concentration of CYP1A2 Substrates. Management: Consider alternatives to such combinations whenever possible, particularly if the CYP1A2 substrate has a relatively narrow therapeutic index. Methotrimeprazine: CNS Depressants may enhance the CNS depressant effect of Methotrimeprazine. Methotrimeprazine may enhance the CNS depressant effect of CNS Depressants. Management: Reduce adult dose of CNS depressant agents by 50% with initiation of concomitant methotrimeprazine therapy. Further CNS depressant dosage adjustments should be initiated only after clinically effective methotrimeprazine dose is established. After inserting needle into muscle, but prior to injection, aspiration should be maintained for several seconds to ensure that no blood is drawn into the syringe; if any blood is aspirated, discard syringe and start over with fresh drug from a new kit. July 5, 2016. Olanzapine oral medical facts from Drugs. If any of these effects persist or worsen, notify your doctor or promptly. Taking olanzapine with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures. benadryl



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Olanzapine ingredients

Klonopin for anxiety and insomnia. My physician never warned me about dependence. I was probably on this drug for 18 months. Cmax and AUC of oral olanzapine by about 60%. As peak olanzapine levels are not typically obtained until about 6 hours after dosing, charcoal may be a useful treatment for olanzapine overdose. Paul Law tells WebMD. "One child is on 56 treatments at one time. Read and sign the Informed Consent form provided by your doctor. If you have any questions, ask your doctor or pharmacist.

Common side effects of olanzapine

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Are you suffering from Health Anxiety?

Olanzapine tablets comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get olanzapine tablets refilled. May 3, 2016. Side Effects of Zyprexa, Zyprexa Zydis Olanzapine Drug. Single doses of olanzapine did not affect the pharmacokinetics of imipramine or its active metabolite desipramine.

Before taking olanzapine

Drowsiness, confusion, and dizziness can increase the risk of falling. Olanzapine is not approved by the FDA for use in the treatment of behavioral disorders in elderly patients with dementia. Agranulocytosis has also been reported.

Restricted distribution program: Zyprexa Relprevv is only available under a restricted distribution program. Only prescribers, health care facilities, and pharmacies registered with the program are able to prescribe, distribute, or dispense Zyprexa Relprevv for patients who are enrolled in and meet all conditions of the program. In clinical studies, changes in prolactin levels were found to be statistically significantly different based on dose, higher doses were associated with higher levels of prolactin. In a study of up to 12 weeks, plasma prolactin concentrations exceeded the upper limit of normal ULN in approximately 30% of patients who had normal baseline prolactin values. The majority of these elevations were mild, and remained below 2 x ULN.

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